* FOR: Women & Men
* Rim Type: Semi-Rimless
* Features: Mirrored
* Looks best on these face shapes: All shapes
Chemistry Biochemistry A significant correlation exists between elevated levels of lipoprotein(a) [Lp(a)] and the development of cardiovascular disease in human populations.
The nature of this correlation is unclear, however, since the biological role of Lp(a) has not been determined. Lp(a) is distinguishable from low density lipoprotein (LDL) by the presence of apolipoprotein(a) [apo(a)] which likely renders the unique structural and functional properties attributed to Lp(a). Apo(a) is characterized gold oakleys by the presence of multiply repeated copies of a sequence resembling plasminogen kringle IV. The size of the repeated region in apo(a) is variable, giving rise to the occurrence of a number of differently sized isoforms in the population. Although apo(a) has been demonstrated to interact with a variety of plasma and cellular components, the biological relevance of these observations remains unknown. My laboratory is engaged in studies addressing structure function relationships in apo(a), using molecular biology, protein chemistry, cell biology, and proteomic techniques. Apolipoprotein(a) stimulates vascular endothelial cell growth and migration and signals through integrin alphavbeta3. Biochemical Journal, in press, 2008. Effect of single nucleotide polymorphisms on expression of the gene oakley men glasses encoding thrombin activatable fibrinolysis inhibitor: a functional analysis. Blood 1, 183 189 (2008). A polymorphism in apolipoprotein(a) is associated with severe coronary disease. Arterioscler. Thromb. Vasc. Biol. 9, 2030 2036 (2007). Molecular analysis of the human thrombin activable fibrinolysis inhibitor promoter. Br J Haematol. 138, 231 44 (2007). NMR solution structure, dynamics and binding properties of the kringle IV type 8 module of apolipoprotein(a). Catalysis of covalent Lp(a) assembly: Evidence for an extracellular enzyme activity that enhances disulfide bond formation. Biochemistry 45, 9919 9928 (2006). An apolipoprotein(a) peptide delays chylomicron remnant clearance and increases plasma remnant lipoproteins and atherosclerosis in vivo. Arterioscler. Thromb. Vasc. Biol. Baboon lipoprotein(a) binds very weakly to lysine agarose and fibrin despite the presence of a strong lysine binding site in apolipoprotein(a) kringle IV type 10. Stimulation of vascular smooth muscle cell proliferation oakley sunglasses for men and migration by apolipoprotein(a) is dependent on inhibition of TGF beta activation and on the presence of kringle IV type 9. J. Biol.
Chem. Identification of sequences in apolipoprotein(a) that maintain its closed conformation: a novel role oakley half jacket for apo(a) isoform size in determining the efficiency of covalent Lp(a) formation. Biochemistry 43, 9978 9988 (2004).
Prev: replacement oakley lenses